| 1963 |
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• The third generation of the Costopoulos family enters the Bank: Yannis S. Costopoulos is assigned to the Loans Section of the Main Branch and Fotis P. Costopoulos to the Legal Department of the Bank.
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 Inauguration of the Ioannina Branch, 1965. From left to right: Yannis S. Costopoulos, Fotis P. Costopoulos and Constantinos S. Manouilides, architect and, later, Technical Adviser of the Bank. Photograph Alpha Bank Historical Archives
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| 1964 |
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• The Bank secures a firm presence in Thessaloniki with the construction of a privately-owned building at Mitropoleos Street, which houses the Main Branch of the city.
• In a systematic effort to reorganise the responsibilities of the Divisions, the Bank establishes a new structure articulated around six Central Divisions.
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 The transactions area of the Main (Mitropoleos) Branch in Thessaloniki Photograph Alpha Bank Historical Archives
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| 1968 |
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• On the death of Stavros J. Costopoulos, his brother Spyros J. Costopoulos is elected Chairman of the Board of Directors, while retaining his responsibilities as Managing Director of the Bank.
• Yannis S. Costopoulos is elected member of the Board of Directors of the Bank and Fotis P. Costopoulos follows a few months later.
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 Spyros J. Costopoulos Chairman of the Board of Directors of the Commercial Credit Bank Photograph Alpha Bank Historical Archives
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| 1969 |
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• Inauguration of the extension of the Main Building facilities of the Bank in Athens, an event that coincides with the 90th anniversary of the Bank.
• Spyros J. Costopoulos is succeeded by Fotis P. Costopoulos as the Chairman of the Board of Directors of ''La Commerciale'' S.A. d’ Assurances Générales.
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 The extension of the Main Building of the Bank at Stadiou Street Photograph Alpha Bank Historical Archives
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